Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 4/20 | 0.88 |
| ▸ | MMP2 | P08253 | 3/20 | 0.81 |
| ▸ | MMP9 | P14780 | 3/20 | 0.81 |
| ▸ | MMP8 | P22894 | 3/20 | 0.81 |
| ▸ | MMP13 | P45452 | 3/20 | 0.81 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3917809 | 1.00 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6281518 | 0.94 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL8820125 | 0.94 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL2242293 | 0.90 | MMP2 (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381560 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381859 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381547 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381564 | 0.88 | CHEK2 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202512 | 0.88 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202550 | 0.88 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495000-A4 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE A1A ADRENOCEPTOR BLOCKERS | RANBAXY LAB LTD (IN) | 2005-10-05 | — | — | EP | disclosed |
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |
| EP-1495000-A1 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE A1A ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES, LTD. (IN) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003084928-A1 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE Α1Α ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (IN) | 2003-10-16 | — | — | WO | disclosed |