Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 4/20 | 0.88 |
| ▸ | MMP2 | P08253 | 3/20 | 0.81 |
| ▸ | MMP9 | P14780 | 3/20 | 0.81 |
| ▸ | MMP8 | P22894 | 3/20 | 0.81 |
| ▸ | MMP13 | P45452 | 3/20 | 0.81 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259448 | 1.00 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6281518 | 0.94 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL8820125 | 0.94 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL2242293 | 0.90 | MMP2 (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381560 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381859 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381547 | 0.89 | PRSS12 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14381564 | 0.88 | CHEK2 (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202512 | 0.88 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202550 | 0.88 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | claimed |
| US-7504414-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080009493-A1 | Substituted Benzimidazoles and Imidazo-[4,5]-Pyridines | ARIENTI KRISTEN L | 2008-01-10 | — | — | US | disclosed |
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009493-A1 | Substituted Benzimidazoles and Imidazo-[4,5]-Pyridines | CDKN1A, DDB1, TMBIM6 | HPSE 3576/4885MMP2 4666/4885MMP9 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.