Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436373 | 0.85 | ABCB11 (0.71) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL6260778 | 0.85 | ABCB11 (0.71) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL10436377 | 0.85 | ABCB11 (0.71) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL682291 | 0.85 | ABCB11 (0.71) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL2477480 | 0.85 | ABCB11 (0.71) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL960224 | 0.84 | LMNA (0.77) | LMNAABCB11MAPTMAPK1KDM4E | |
| SCHEMBL11290405 | 0.84 | LMNA (0.77) | LMNAABCB11MAPTMAPK1KDM4E | |
| SCHEMBL20338964 | 0.84 | ABCB11 (0.70) | LMNAABCB11MAPTMAPK1MEN1 | |
| SCHEMBL11292589 | 0.83 | LMNA (0.65) | LMNAABCB11MAPTMAPK1KDM4E | |
| SCHEMBL11295543 | 0.83 | LMNA (0.75) | LMNAABCB11MAPTMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275390-B1 | Medicament for treatment of heart failure | WOLF HORST P O (DE) | 2005-11-02 | — | — | EP | claimed |
| EP-0231367-B1 | USE OF OXIRANCARBOXYLIC ACIDS FOR THE TREATMENT OF HYPERLIPEMIA | Wolf, Horst P.O., Dr. (DE) | 1991-07-24 | — | — | EP | claimed |