Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960224 | 1.00 | LMNA (0.77) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| SCHEMBL11295543 | 0.99 | LMNA (0.75) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| SCHEMBL11292589 | 0.92 | LMNA (0.65) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Rac-Etomoxir SCHEMBL681359 | 0.87 | ABCB11 (1.00) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| SCHEMBL954683 | 0.87 | ABCB11 (1.00) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Etomoxir SCHEMBL49075 | 0.87 | ABCB11 (1.00) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Rac-Etomoxir SCHEMBL15256787 | 0.87 | ABCB11 (1.00) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Etomoxir SCHEMBL12813827 | 0.86 | MAPT (0.98) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Etomoxir SCHEMBL5883664 | 0.86 | MAPT (0.98) | LMNAABCB11MAPTMAPK1ALDH1A1 | |
| Rac-Etomoxir SCHEMBL2141141 | 0.85 | MAPT (0.95) | LMNAABCB11MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337267-A | HYPOKETONEMIC, HYPOGLYCEMIC, ANTIDIABETIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-29 | — | — | US | disclosed |