Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 5/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234134 | 0.93 | GPR119 (0.57) | GPR119ARCHRM4PANK3KDM4E | |
| SCHEMBL2224211 | 0.82 | MAP4K4 (0.50) | GPR119KDM4EALDH1A1L3MBTL1SMO | |
| SCHEMBL29462081 | 0.82 | RET (0.48) | GPR119CHRM4PANK3KDM4EALDH1A1 | |
| SCHEMBL3051541 | 0.81 | CNR2 (0.54) | GPR119ARPANK3KDM4EALDH1A1 | |
| SCHEMBL29514660 | 0.79 | KDM4E (0.54) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14844043 | 0.79 | SMO (0.56) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3048925 | 0.79 | KDM4E (0.54) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL12683464 | 0.79 | GPR119 (0.46) | GPR119CHRM4PANK3KDM4EALDH1A1 | |
| SCHEMBL6232964 | 0.79 | MAP4K4 (0.52) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21135514 | 0.79 | MAP4K4 (0.52) | GPR119CHRM4PANK3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |