Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224211 | 0.80 | MAP4K4 (0.50) | MAP4K4DPP4DPP8DPP9DPP7 | |
| SCHEMBL29462081 | 0.80 | RET (0.48) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL6259732 | 0.79 | GPR119 (0.50) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL3048925 | 0.77 | KDM4E (0.54) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14844043 | 0.77 | SMO (0.56) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL29514660 | 0.77 | KDM4E (0.54) | GPR119PANK3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL24493347 | 0.77 | PDK1 (0.49) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL21135514 | 0.77 | MAP4K4 (0.52) | MAP4K4DPP4DPP8DPP9DPP7 | |
| SCHEMBL24493349 | 0.77 | PDK1 (0.49) | DPP4DPP8DPP9DPP7GPR119 | |
| SCHEMBL12683464 | 0.77 | GPR119 (0.46) | MAP4K4GPR119PANK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |