Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752253 | 0.80 | HPGD (0.32) | HPGDGPR84 | |
| SCHEMBL9958782 | 0.79 | GPR84 (0.33) | GPR84 | |
| SCHEMBL655965 | 0.79 | TGM2 (0.33) | MEN1KMT2AALDH1A1BLMCDC25B | |
| SCHEMBL8507994 | 0.74 | BLM (0.38) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL5310650 | 0.73 | CDC25B (0.40) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL989080 | 0.71 | BACE1 (0.47) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL8132104 | 0.71 | KDM4E (0.34) | MEN1KMT2AALDH1A1HPGDATM | |
| SCHEMBL8508617 | 0.71 | GPR84 (0.37) | MAPTALDH1A1HPGDBLMKDM4E | |
| SCHEMBL8204473 | 0.70 | KDM4E (0.35) | MAPTKMT2AALDH1A1HPGDBLM | |
| SCHEMBL5001270 | 0.70 | CYP1A2 (0.33) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509532-A1 | 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003099827-A1 | 1-THIA-3-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-12-04 | — | — | WO | disclosed |