Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 4/20 | 0.38 |
| ▸ | TYMS | P04818 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820782 | 0.75 | CYP2D6 (0.48) | MAPTGAAPKMCFTRGOPC | |
| SCHEMBL4726170 | 0.73 | CFTR (0.61) | MAPTGAAPKMCFTRGOPC | |
| SCHEMBL1823331 | 0.71 | CFTR (0.46) | MAPTGAAPKMCFTRGOPC | |
| SCHEMBL4726524 | 0.71 | CFTR (0.46) | MAPTGAAPKMCFTRGOPC | |
| SCHEMBL11011777 | 0.69 | CFTR (0.44) | MAPTCFTRGOPCDHFRTYMS | |
| SCHEMBL4728501 | 0.68 | HCAR3 (0.44) | MAPTCFTRGOPCLMNATP53 | |
| SCHEMBL4727744 | 0.64 | CFTR (0.44) | MAPTGAAPKMCFTRGOPC | |
| (R)-Chlorthalidone SCHEMBL30872862 | 0.63 | CA1 (1.00) | MAPTCA12CA1CA2CA3 | |
| Chlorthalidone SCHEMBL164949 | 0.63 | CA1 (1.00) | MAPTCA12CA1CA2CA3 | |
| Chlorthalidone SCHEMBL4425734 | 0.63 | CA1 (1.00) | MAPTCA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005065046-A2 | AN EFFICIENT INDUSTRIAL PROCESS FOR 3-HYDROXY-3-(3’-SULFAMYL-4’-CHLOROPHENYL)PHTALIMIDINE | IPCA LABORATORIES LIMITED (IN) | 2005-07-21 | — | — | WO | disclosed |
| US-4322356-A | Method of preparing substituted phthalides | THE DOW CHEMICAL CO. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4188330-A | Substituted phthalide derivatives | THE DOW CHEMICAL COMPANY (US) | 1980-02-12 | — | — | US | disclosed |