Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.61 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820782 | 0.87 | CYP2D6 (0.48) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL1823331 | 0.86 | CFTR (0.46) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL4726524 | 0.82 | CFTR (0.46) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL4729629 | 0.80 | OPRM1 (0.53) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL4728501 | 0.78 | HCAR3 (0.44) | CFTRGOPCNPSR1CYP2C9CYP2C19 | |
| SCHEMBL4727744 | 0.78 | CFTR (0.44) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL4725746 | 0.76 | TP53 (0.48) | CFTRGOPCNPSR1GAACYP2C9 | |
| SCHEMBL17922501 | 0.76 | CFTR (0.55) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL3886398 | 0.76 | CFTR (1.00) | CFTRGOPCNPSR1GAAPKM | |
| SCHEMBL17525320 | 0.76 | CFTR (0.66) | CFTRGOPCNPSR1GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3086859-A | — | — | None | — | — | JP | disclosed |
| JP-2117670-A | — | — | None | — | — | JP | disclosed |
| EP-1786773-B1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RES TECH LTD (GB) | 2017-03-01 | — | — | EP | disclosed |
| EP-1786773-B1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RES TECH LTD (GB) | 2017-03-01 | — | — | EP | disclosed |
| US-8258175-B2 | Prodrug; novel series of compounds which inhibit the MDM2-p53 interaction and have in vitro activity exerting an anti-tumour effect; cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| US-8258175-B2 | Prodrug; novel series of compounds which inhibit the MDM2-p53 interaction and have in vitro activity exerting an anti-tumour effect; cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| US-8258175-B2 | Prodrug; novel series of compounds which inhibit the MDM2-p53 interaction and have in vitro activity exerting an anti-tumour effect; cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-04 | — | — | US | disclosed |
| US-20080261917-A1 | Isoindolin-1-One Derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080261917-A1 | Isoindolin-1-One Derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080261917-A1 | Isoindolin-1-One Derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-10-23 | — | — | US | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |
| JP-H0386859-A | ORGANIC PEROXIDE AND ITS USE | NIPPON OIL & FATS CO LTD | 1991-04-11 | — | — | JP | disclosed |
| JP-H02117670-A | NOVEL ORGANIC PEROXIDE | NIPPON OIL & FATS CO LTD | 1990-05-02 | — | — | JP | disclosed |
| US-4688059-A | 3-ARYL(OR HETEROARYL)-3-(OXY OR THIO)PHTHALIDE AS REAGENT IN CARBONLESS DUPLICATING SYSTEM | THE HILTON-DAVIS CHEMICAL CO. (US) | 1987-08-18 | — | — | US | disclosed |
| US-4661605-A | CARBONLESS CUPLICATION AND THERMAL MARKING SYSTEMS | THE HILTON-DAVIS CHEMICAL CO. (US) | 1987-04-28 | — | — | US | disclosed |
| US-4535172-A | FOR CARBONLESS DUPLICATING AND THERMAL MARKING SYSTEMS | THE HILTON-DAVIS CHEMICAL CO. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4505921-A | Sulfonylurea compounds and their use in treating diabetes | ADIR, S.A.R.L. (FR) | 1985-03-19 | — | — | US | disclosed |
| US-4500636-A | CONTAINING PHENYL SUBSTITUTED ISOBENZOFURAN BLOCKET PHOTOGRAPHIC AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1985-02-19 | — | — | US | disclosed |
| US-4058529-A | Polycyclic amino derivatives of pyrrolidone and piperidone | CIBA-GEIGY CORPORATION (US) | 1977-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261917-A1 | Isoindolin-1-One Derivatives | HCN3, NHERF1, SIGMAR1 | CFTR 408/4885GOPC 4613/4885NPSR1 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.