Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259081 | 0.79 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13107316 | 0.77 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13107313 | 0.77 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3443490 | 0.77 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7570645 | 0.74 | HDAC4 (0.43) | OPRM1OPRD1OPRK1OPRL1PSEN1 | |
| SCHEMBL7564524 | 0.73 | PSEN1 (0.43) | OPRM1OPRD1OPRK1OPRL1PSEN1 | |
| SCHEMBL4445384 | 0.73 | HDAC4 (0.40) | OPRM1OPRK1KMT2AALDH1A1HDAC3 | |
| SCHEMBL14388188 | 0.71 | SIGMAR1 (0.41) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL30040141 | 0.70 | APP (0.46) | SIGMAR1KMT2AHTTALDH1A1LPAR1 | |
| SCHEMBL21034069 | 0.70 | APP (0.46) | SIGMAR1KMT2AHTTALDH1A1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077463-A2 | LIGAND FOR A MONOAMINE RECEPTOR OR TRANSPORTER FOR TREATING ADDICTION OR DEPENDENCE | SEPRACOR INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| EP-1318988-A2 | LIGANDS FOR MONOAMINE RECEPTORS AND TRANSPORTERS, AND METHODS OF USE THEREOF (NEUROTRANSMISSION) | Sepracor, Inc. (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002022572-A2 | LIGANDS FOR MONOAMINE RECEPTORS AND TRANSPORTERS, AND METHODS OF USE THEREOF (NEUROTRANSMISSION) | SEPRACOR, INC. (US) | 2002-03-21 | — | — | WO | disclosed |