Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564524 | 0.98 | PSEN1 (0.43) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7571494 | 0.86 | P2RX7 (0.35) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4445384 | 0.76 | HDAC4 (0.40) | HDAC4PDE7ASLC6A4OPRM1OPRK1 | |
| SCHEMBL4437244 | 0.74 | HDAC4 (0.43) | HDAC4PDE7AHSD11B1 | |
| SCHEMBL13755347 | 0.74 | HDAC4 (0.45) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6260698 | 0.74 | SIGMAR1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20428043 | 0.71 | HDAC4 (0.42) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21937614 | 0.70 | HDAC4 (0.40) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4435176 | 0.70 | MEN1 (0.36) | HDAC4SLC6A4SLC6A3OPRM1OPRK1 | |
| SCHEMBL9116253 | 0.69 | HDAC4 (0.36) | HDAC4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083863-A2 | THIAZOLE AND OTHER HETEROCYCLIC LIGANDS AND USE THEREOF | SEPRACOR, INC. (US) | 2002-10-24 | — | — | WO | disclosed |