Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.40 |
| ▸ | BCL2 | P10415 | 4/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093439 | 0.84 | DUT (0.51) | DUTCDK4CCND1MCL1BCL2 | |
| SCHEMBL6029849 | 0.82 | CDK4 (0.57) | DUTHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL6030247 | 0.79 | HTR2A (0.54) | DUTHTR2AHTR2CMCL1 | |
| SCHEMBL9091990 | 0.78 | HTR2A (0.48) | DUTHTR2AHTR2C | |
| SCHEMBL3997142 | 0.77 | PRKCI (0.45) | DUTHTR2AHTR2CPLGPLAU | |
| SCHEMBL6402168 | 0.77 | ACLY (0.37) | DUTHTR2AHTR2CACLYMCL1 | |
| SCHEMBL9094075 | 0.77 | DUT (0.51) | DUTHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL7213163 | 0.76 | DUT (0.41) | DUTHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL18856955 | 0.75 | HTR2A (0.56) | HTR2AHTR2CACLYCDK4CCND1 | |
| SCHEMBL8252214 | 0.75 | DUT (0.49) | DUTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005034837-A2 | 7H-IMIDAZO [1,2-α] PYRAZIN-8-ONE COMPOUNDS AS ION CHANNEL MODULATORS | CARDIOME PHARMA CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |