Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 13/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093674 | 0.93 | DUT (0.41) | DUTMCL1HTR2AHTR2C | |
| SCHEMBL9093439 | 0.90 | DUT (0.51) | DUTMCL1CDK4CCND1 | |
| SCHEMBL6030247 | 0.83 | HTR2A (0.54) | DUTMCL1HTR2AHTR2C | |
| SCHEMBL7213163 | 0.82 | DUT (0.41) | DUTMCL1HTR2AHTR2CCDK4 | |
| SCHEMBL8252214 | 0.81 | DUT (0.49) | DUTMCL1 | |
| SCHEMBL6029849 | 0.81 | CDK4 (0.57) | DUTHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL9091825 | 0.79 | DUT (0.44) | DUT | |
| SCHEMBL6260801 | 0.77 | DUT (0.52) | DUTMCL1HTR2AHTR2CCDK4 | |
| SCHEMBL4001230 | 0.76 | DUT (0.45) | DUTMCL1HTR2AHTR2C | |
| SCHEMBL9092781 | 0.76 | HTR7 (0.49) | DUTMCL1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532088-B1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO INC (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5349061-A | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1994-09-20 | — | — | US | disclosed |
| US-5310901-A | Autoimmune diseases; antiinflammatory agents; fungicides; prevention of organ transplant rejection; alkylation and/or arylation at C-42 | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5252732-A | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity | MERCK & CO., INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0532088-A1 | O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl macrolides | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | disclosed |