Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CASP2 | P42575 | 2/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | CASP6 | P55212 | 2/20 | 0.62 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12857843 | 0.94 | CASP3 (0.79) | CASP3ALDH1A1KDM4EHPGDCASP2 | |
| SCHEMBL12857891 | 0.88 | CASP3 (0.58) | CASP3ALDH1A1KDM4EHPGDALOX12 | |
| SCHEMBL6261674 | 0.86 | KDM4E (0.76) | CASP3ALDH1A1KDM4EHPGDALOX12 | |
| SCHEMBL4296330 | 0.85 | TERT (0.68) | ALDH1A1MAPTGAAHTTPOLB | |
| SCHEMBL12857644 | 0.80 | CASP3 (0.74) | CASP3ALDH1A1KDM4EMAPTCASP2 | |
| SCHEMBL12857937 | 0.80 | CASP3 (0.67) | CASP3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL5639950 | 0.80 | CASP3 (0.68) | CASP3ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL28854755 | 0.78 | KDM4E (0.75) | CASP3ALDH1A1KDM4EHPGDALOX12 | |
| SCHEMBL6263621 | 0.77 | KMT2A (0.77) | CASP3ALDH1A1KDM4EHPGDALOX12 | |
| SCHEMBL6259068 | 0.77 | GSK3B (0.80) | CASP3ALDH1A1KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | GREEN JEREMY (US) | 2005-08-18 | — | — | US | claimed |
| WO-2005039564-A1 | PHTHALIMIDE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-05-06 | — | — | WO | claimed |
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | GREEN JEREMY (US) | 2005-08-18 | — | — | US | disclosed |
| WO-2005039564-A1 | PHTHALIMIDE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | PDK1, PDPK1, MTOR | CASP3 2856/4885ALDH1A1 3870/4885KDM4E 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.