Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718238 | 0.85 | HTR1A (0.69) | HTR1AHTR1DHTR1B | |
| SCHEMBL6714770 | 0.81 | HTR1A (0.56) | HTR1AHTR1DHTR1BL3MBTL1SMN1; SMN2 | |
| SCHEMBL6724427 | 0.80 | L3MBTL1 (0.47) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL6220946 | 0.80 | MEN1 (0.47) | HTR1AHTR1DHTR1BL3MBTL1SMN1; SMN2 | |
| SCHEMBL6223661 | 0.79 | NAMPT (0.49) | HTR1AHTR1DHTR1BL3MBTL1SMN1; SMN2 | |
| SCHEMBL6222627 | 0.79 | MEN1 (0.43) | HTR1AHTR1DHTR1BL3MBTL1 | |
| SCHEMBL6724719 | 0.79 | HTR1A (0.52) | HTR1AHTR1DHTR1BL3MBTL1SMN1; SMN2 | |
| SCHEMBL6222169 | 0.79 | NAMPT (0.48) | L3MBTL1THRB | |
| SCHEMBL6718478 | 0.79 | MAPT (0.55) | HTR1AHTR1DHTR1BL3MBTL1SMN1; SMN2 | |
| SCHEMBL6717656 | 0.79 | HTR1A (0.64) | HTR1AHTR1DHTR1BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343796-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2005-01-12 | — | — | EP | disclosed |
| EP-1343796-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002034760-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-02 | — | — | WO | disclosed |