Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868796 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HTTMAPTLMNANPC1 | |
| Isoquinoline SCHEMBL10651325 | 0.78 | KMT2A (0.35) | ALDH1A1MAOAMAOBHPGDAPAF1 | |
| SCHEMBL675941 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MAOAMAOBHPGDAPAF1 | |
| Naphthalene SCHEMBL7327012 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL31588723 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL29355164 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL9654 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL30286035 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL1536317 | 0.71 | TNF (0.48) | MAOAMAOBHTTTNFMAPT | |
| Isoquinoline SCHEMBL6612840 | 0.69 | CYP1A2 (0.48) | HTTTNFMAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161499-A1 | Process for preparation of aminophthalideisoquinolines | MITSUBISHI KASEI CORPORATION (JP) | 1985-11-21 | — | — | EP | claimed |
| WO-2005020911-A2 | BENZO[1, 3]DIOXOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESSES OF MAKING AND USING THE SAME | ATHERSYS, INC. (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20050049278-A1 | Benzo[1,3]dioxole compounds, pharmaceutical compositions thereof, and processes of making and using the same | ATHERSYS, INC. | 2005-03-03 | — | — | US | disclosed |
| EP-0161499-B1 | PROCESS FOR PREPARATION OF AMINOPHTHALIDEISOQUINOLINES | MITSUBISHI KASEI CORPORATION (JP) | 1988-07-27 | — | — | EP | disclosed |
| EP-0161499-A1 | Process for preparation of aminophthalideisoquinolines | MITSUBISHI KASEI CORPORATION (JP) | 1985-11-21 | — | — | EP | disclosed |
| EP-0161499-A1 | Process for preparation of aminophthalideisoquinolines | MITSUBISHI KASEI CORPORATION (JP) | 1985-11-21 | — | — | EP | disclosed |
| EP-0161499-A1 | Process for preparation of aminophthalideisoquinolines | MITSUBISHI KASEI CORPORATION (JP) | 1985-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049278-A1 | Benzo[1,3]dioxole compounds, pharmaceutical compositions thereof, and processes of making and using the same | CYP4X1, BBOX1, CYP1B1 | ALDH1A1 297/4885MAOA 373/4885MAOB 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.