Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.64 |
| ▸ | MMP1 | P03956 | 18/20 | 0.64 |
| ▸ | MMP9 | P14780 | 18/20 | 0.64 |
| ▸ | MMP13 | P45452 | 18/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267659 | 0.92 | ADAM17 (0.75) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6266026 | 0.92 | ADAM17 (0.65) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6567143 | 0.91 | MMP9 (0.71) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6261484 | 0.90 | ADAM17 (0.76) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6568639 | 0.87 | MMP9 (0.75) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL6567145 | 0.87 | MMP1 (0.73) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL3942419 | 0.86 | ADAM17 (0.84) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6568599 | 0.86 | MMP1 (0.74) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6568497 | 0.86 | MMP1 (0.71) | ADAM17MMP1MMP9MMP13MMP2 | |
| SCHEMBL6565370 | 0.84 | MMP1 (0.77) | ADAM17MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |