Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315735 | 0.89 | NOTUM (0.51) | NOTUMSIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL1102007 | 0.84 | ALDH1A1 (0.48) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL8972513 | 0.81 | SLC6A2 (0.41) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL25112007 | 0.81 | SLC6A2 (0.49) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL14060360 | 0.81 | ALDH1A1 (0.46) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL16600454 | 0.81 | ALDH1A1 (0.46) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL21085252 | 0.81 | ALDH1A1 (0.46) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL11852260 | 0.81 | GAA (0.47) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL10434906 | 0.80 | SLC6A2 (0.52) | SLC6A2SLC6A4NOTUMSIGMAR1GAA | |
| SCHEMBL27675111 | 0.80 | GAA (0.56) | SLC6A2SLC6A4NOTUMGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251171-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | BACH ANDREW THOMAS | 2011-10-13 | — | — | US | disclosed |
| US-20090118160-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | BACH ANDREW THOMAS | 2009-05-07 | — | — | US | disclosed |
| EP-1002824-B1 | AMINATED POLYSILAZANE AND PROCESS FOR THE PREPARATION THEREOF | AZ ELECTRONIC MATERIALS USA (US) | 2005-11-09 | — | — | EP | disclosed |
| CN-1204121-C | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2005-06-01 | — | — | CN | disclosed |
| US-6310168-B1 | POLYSILAZANES WITH OXY PENDANT GOUPS | TONEN CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-1002824-A1 | AMINATED POLYSILAZANE AND PROCESS FOR THE PREPARATION THEREOF | Tonen Corporation (JP) | 2000-05-24 | — | — | EP | disclosed |
| CN-1253547-A | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2000-05-17 | — | — | CN | disclosed |
| EP-0441222-B1 | Process and electrode system for determining an analyte or an oxidoreductase as well as suitable compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1996-12-18 | — | — | EP | disclosed |
| CN-1026248-C | Method and sensing electrode system for electrochemical determination of analytes and oxidoreductases | BOEHRINGER MANNHEIM GMBH | 1994-10-19 | — | — | CN | disclosed |
| US-5286362-A | Reducible substance is enzymatically reduced and oxidized at the electrode; substance formed by oxidation is different from the reducible substance used initially | BOEHRINGER MANNHEIM GMBH (DE) | 1994-02-15 | — | — | US | disclosed |
| US-5202938-A | Laminated waveguiding polarizer utilizing polymeric birefringent cladding | HOECHST CELANESE CORP. (US) | 1993-04-13 | — | — | US | disclosed |
| US-5171803-A | Copolymer with side chains exhibiting nonlinear optical response | HOECHST CELANESE CORP. | 1992-12-15 | — | — | US | disclosed |
| US-5122244-A | Having a reducible nitroso or oxime compound to transfer electrons leading to a signal and form an aromatic amine oxidizable to a compound different from the original; low voltage | BOEHRINGER MANNHEIM GMBH (DE) | 1992-06-16 | — | — | US | disclosed |
| CN-1054666-A | Be used for the method for electrochemical determination of analyte or oxidoreducing enzyme and sensitive electrode system and for this reason and the compound that uses | BOEHRINGER MANNHEIM GMBH (DE) | 1991-09-18 | — | — | CN | disclosed |
| EP-0441222-A2 | Process and electrode system for determining an analyte or an oxidoreductase as well as suitable compounds | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118160-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | PPARG, PPARA, PPARD | SLC6A2 4600/4885SLC6A4 4665/4885NOTUM 2236/4885 |
| US-20110251171-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | PPARG, PPARA, PPARD | SLC6A2 4600/4885SLC6A4 4665/4885NOTUM 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.