Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | GLA | P06280 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267202 | 0.83 | CA9 (0.49) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL8527989 | 0.80 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL6264833 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL14282664 | 0.73 | HTR1A (0.45) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL14282661 | 0.73 | HTR1A (0.45) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL11490595 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1ALOX12 | |
| SCHEMBL11329258 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1ALOX12 | |
| SCHEMBL11320572 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1ALOX12 | |
| SCHEMBL14282662 | 0.72 | LTA4H (0.45) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL11325175 | 0.70 | CNR1 (0.45) | KDM4EALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5455268-A | Treating arthropathy | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-10-03 | — | — | US | claimed |
| WO-2005091960-A2 | METHOD FOR INHIBITING FIBROCARTILAGE DEGRADATION | RUSH UNIVERSITY MEDICAL CENTER (US) | 2005-10-06 | — | — | WO | disclosed |
| US-6750249-B1 | GRADUALLY RELEASE ESCULETIN OR ITS DERIVATIVE IN A CONTROLLED MANNER OVER A LONG PERIOD OF TIME | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-06-15 | — | — | US | disclosed |
| EP-1121931-A1 | CONTROLLED RELEASE ORAL PREPARATIONS OF ESCULETIN AND ITS DERIVATIVES | Kureha Chemical Industry Co., Ltd. (JP) | 2001-08-08 | — | — | EP | disclosed |
| EP-0614896-B1 | Esculetin derivatives and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 1998-12-30 | — | — | EP | disclosed |
| US-5455268-A | Treating arthropathy | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-10-03 | — | — | US | disclosed |
| EP-0614896-A1 | Esculetin derivatives and pharmaceutical composition | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-09-14 | — | — | EP | disclosed |