Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.58 |
| ▸ | MMP2 | P08253 | 15/20 | 0.58 |
| ▸ | MMP13 | P45452 | 14/20 | 0.58 |
| ▸ | MMP14 | P50281 | 13/20 | 0.58 |
| ▸ | MMP1 | P03956 | 11/20 | 0.58 |
| ▸ | MMP9 | P14780 | 8/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263926 | 0.88 | ADAM17 (0.71) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL6263929 | 0.86 | MMP2 (0.50) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL3941487 | 0.85 | ADAM17 (0.67) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL3939437 | 0.85 | ADAM17 (0.54) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL6266477 | 0.82 | ADAM17 (0.85) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL6268038 | 0.80 | ADAM17 (0.58) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL6266622 | 0.77 | ADAM17 (0.85) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL3947781 | 0.76 | ADAM17 (0.61) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL7389379 | 0.76 | ADAM17 (0.44) | ADAM17MMP2MMP13MMP14MMP1 | |
| SCHEMBL6755198 | 0.75 | MMP13 (0.56) | ADAM17MMP2MMP13MMP14MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |