Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 11/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627106 | 1.00 | FYN (0.44) | FYNHASPINCKS1BSKP1SKP2 | |
| SCHEMBL627262 | 0.84 | CCNA2 (0.48) | FYNJAK1 | |
| SCHEMBL627225 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2BTKJAK3 | |
| SCHEMBL627384 | 0.80 | FYN (0.48) | FYNHASPIN | |
| SCHEMBL626399 | 0.79 | KDM1A (0.38) | CKS1BSKP1SKP2JAK1JAK2 | |
| SCHEMBL627192 | 0.78 | BTK (0.45) | CKS1BSKP1SKP2BTKJAK3 | |
| SCHEMBL626893 | 0.77 | PIK3CA (0.49) | FYNHASPIN | |
| SCHEMBL626891 | 0.77 | PIK3CA (0.49) | FYNHASPIN | |
| SCHEMBL628263 | 0.77 | BTK (0.52) | BTKJAK3 | |
| SCHEMBL625500 | 0.77 | FYN (0.55) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |