Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627192 | 0.94 | BTK (0.45) | CKS1BSKP1SKP2CTSKPDE10A | |
| SCHEMBL628263 | 0.88 | BTK (0.52) | CTSKPDE10ABTKJAK3RET | |
| SCHEMBL626886 | 0.85 | CKS1B (0.50) | CKS1BSKP1SKP2LMNATP53 | |
| SCHEMBL627106 | 0.82 | FYN (0.44) | CKS1BSKP1SKP2BTKJAK3 | |
| SCHEMBL626398 | 0.82 | FYN (0.44) | CKS1BSKP1SKP2BTKJAK3 | |
| SCHEMBL627264 | 0.79 | CKS1B (0.43) | CKS1BSKP1SKP2LMNATHRB | |
| SCHEMBL627226 | 0.79 | CKS1B (0.46) | CKS1BSKP1SKP2CTSKPDE10A | |
| SCHEMBL23268357 | 0.78 | RET (0.33) | CKS1BSKP1SKP2CTSKPDE10A | |
| SCHEMBL23268405 | 0.78 | RET (0.33) | CKS1BSKP1SKP2CTSKPDE10A | |
| SCHEMBL23244988 | 0.78 | KCNH2 (0.41) | LMNATHRBTP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |