Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20600150 | 0.92 | LMNA (0.49) | LMNANR1H4CYP2D6CHRM2CHRM1 | |
| SCHEMBL20599883 | 0.92 | LMNA (0.49) | LMNANR1H4CYP2D6CHRM2CHRM1 | |
| SCHEMBL8735443 | 0.83 | LMNA (0.44) | LMNACYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL8477470 | 0.82 | LMNA (0.51) | LMNACHRM3HRH1ATML3MBTL1 | |
| SCHEMBL8481946 | 0.82 | LMNA (0.51) | LMNACHRM3HRH1ATML3MBTL1 | |
| SCHEMBL8477474 | 0.82 | LMNA (0.51) | LMNACHRM3HRH1ATML3MBTL1 | |
| SCHEMBL10123845 | 0.80 | LMNA (0.51) | LMNACYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL8343216 | 0.79 | LMNA (0.53) | LMNACHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL8342637 | 0.79 | LMNA (0.53) | LMNACHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL8339348 | 0.79 | LMNA (0.53) | LMNACHRM2CHRM1CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0348683-A1 | Pharmaceutical compositions containing ibuprofen in combination with a piperidinoalkanol antihistamine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-03 | — | — | EP | claimed |
| WO-2005080971-A1 | SYSTEM AND METHOD FOR PLANAR VOLTAGE-CLAMP ELECTROPHYSIOLOGICAL MEASUREMENTS ON MULTIPLE CELLS AND THEIR USE IN IDENTIFYING AGENTS THAT MODULATE ION CHANNELS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |
| EP-0639976-A1 | USE OF TERFENADINE DERIVATIVES AS ANTIHISTAMINICS IN A HEPATICALLY IMPAIRED PATIENT | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023047-A1 | USE OF TERFENADINE DERIVATIVES AS ANTIHISTAMINICS IN A HEPATICALLY IMPAIRED PATIENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0310999-A1 | Pharmaceutical composition for piperidinoalkanol derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-04-12 | — | — | EP | disclosed |