Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.75 |
| ▸ | MMP13 | P45452 | 15/20 | 0.75 |
| ▸ | MMP1 | P03956 | 12/20 | 0.75 |
| ▸ | MMP9 | P14780 | 9/20 | 0.75 |
| ▸ | MMP2 | P08253 | 4/20 | 0.56 |
| ▸ | MMP14 | P50281 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268734 | 0.92 | ADAM17 (0.76) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6261484 | 0.92 | ADAM17 (0.76) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6266457 | 0.92 | ADAM17 (0.66) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6266888 | 0.92 | ADAM17 (0.76) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6264631 | 0.91 | ADAM17 (0.65) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6265787 | 0.91 | ADAM17 (0.64) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6261927 | 0.89 | ADAM17 (0.78) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6265257 | 0.88 | ADAM17 (0.62) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6567501 | 0.86 | MMP9 (0.73) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL6568497 | 0.86 | MMP1 (0.71) | ADAM17MMP13MMP1MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |