Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 16/20 | 0.45 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.43 |
| ▸ | DLK1 | P80370 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626579 | 0.82 | PIK3CA (0.56) | PIK3CAMAP3K12 | |
| SCHEMBL626269 | 0.80 | F2RL3 (0.44) | PIK3CAMAP3K12F2RL3 | |
| SCHEMBL626145 | 0.78 | F2RL3 (0.43) | PIK3CAMAP3K12F2RL3 | |
| SCHEMBL624389 | 0.75 | MAP3K12 (0.43) | PIK3CAMAP3K12F2RL3DLK1 | |
| SCHEMBL12474086 | 0.74 | PIK3CA (0.47) | PIK3CAMAP3K12F2RL3 | |
| SCHEMBL624412 | 0.74 | MAP3K12 (0.45) | PIK3CAMAP3K12MAPT | |
| SCHEMBL532032 | 0.74 | PIK3CA (0.68) | PIK3CAMAP3K12F2RL3TP53MAPT | |
| SCHEMBL532091 | 0.73 | PIK3CA (0.71) | PIK3CAMAP3K12F2RL3 | |
| SCHEMBL625202 | 0.73 | MAP3K12 (0.43) | MAP3K12TP53MAPT | |
| SCHEMBL533618 | 0.73 | PIK3CA (0.51) | PIK3CAMAP3K12F2RL3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |