⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066956 | 0.86 | TSHR (0.39) | — | |
| SCHEMBL5929221 | 0.84 | CES2 (0.42) | — | |
| SCHEMBL3193277 | 0.81 | CES2 (0.47) | — | |
| SCHEMBL3185717 | 0.81 | CES2 (0.47) | — | |
| SCHEMBL19736112 | 0.76 | EPHX2 (0.30) | — | |
| SCHEMBL805192 | 0.74 | TSHR (0.30) | — | |
| SCHEMBL19054518 | 0.72 | — | — | |
| SCHEMBL23743496 | 0.71 | ALDH1A1 (0.50) | — | |
| SCHEMBL15140884 | 0.71 | HPGD (0.37) | — | |
| SCHEMBL23418989 | 0.70 | NOS2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419297-B1 | Process for the separation of optical isomers from 1,4-dihydropyridine derivatives | ADIR (FR) | 1994-06-08 | — | — | EP | claimed |
| EP-0259206-B1 | DERIVATIVES OF 1,4-DIHYDROPYRIDINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1991-10-09 | — | — | EP | claimed |
| EP-0419297-A1 | Process for the separation of optical isomers from 1,4-dihydropyridine derivatives | ADIR ET COMPAGNIE (FR) | 1991-03-27 | — | — | EP | claimed |
| EP-0259206-A1 | Derivatives of 1,4-dihydropyridine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1988-03-09 | — | — | EP | claimed |
| WO-2021139595-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| EP-1606244-A2 | CYCLOALKYLAMIDES AND THEIR THERAPEUTIC USE AS ANTIEPILEPTIC AND ANTICONVULSANT | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20040209858-A1 | Cycloalkylamides and their therapeutic applications | ABBOTT LABORATORIES | 2004-10-21 | — | — | US | disclosed |
| WO-2004037769-A2 | CYCLOALKYLAMIDES AND THEIR THERAPEUTIC USE AS ANTIEPILEPTIC AND ANTICONVULSANT | ABBOTT LABORATORIES (US) | 2004-05-06 | — | — | WO | disclosed |
| US-20040077618-A1 | Cycloalkylamides and their therapeutic applications | ABBOTT LABORATORIES | 2004-04-22 | — | — | US | disclosed |
| EP-0775132-B1 | (AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS | PFIZER LTD (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-5968923-A | ANTIINFLAMMATORY AGENTS, TREATMENT OF NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0349195-B1 | Direct synthesis by cationic polymerization of nitrogen-containing polymers | EXXON CHEMICAL PATENTS INC (US) | 1997-05-21 | — | — | EP | disclosed |
| EP-0419297-A1 | Process for the separation of optical isomers from 1,4-dihydropyridine derivatives | ADIR ET COMPAGNIE (FR) | 1991-03-27 | — | — | EP | disclosed |
| EP-0349195-A2 | Direct synthesis by cationic polymerization of nitrogen-containing polymers | EXXON CHEMICAL PATENTS INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| EP-0128654-B1 | GEM-DIAMINOALKANE DERIVED SWEETENERS | CUMBERLAND PACKING CORPORATION (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0259206-A1 | Derivatives of 1,4-dihydropyridine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1988-03-09 | — | — | EP | disclosed |
| EP-0259206-A1 | Derivatives of 1,4-dihydropyridine, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1988-03-09 | — | — | EP | disclosed |
| EP-0242896-A2 | Novel intermediates useful in the production of gem-diaminoalkane derived sweeteners | CUMBERLAND PACKING CORPORATION (US) | 1987-10-28 | — | — | EP | disclosed |
| US-4571345-A | 1,1-Diaminoalkane derived sweeteners | CUMBERLAND PACKING CORP. (US) | 1986-02-18 | — | — | US | disclosed |
| EP-0128654-A2 | Gem-diaminoalkane derived sweeteners | CUMBERLAND PACKING CORPORATION (US) | 1984-12-19 | — | — | EP | disclosed |