Sugi Predict

Sugi Predict / Compounds / SCHEMBL6267516

SCHEMBL6267516

SCHEMBL6267516

O=C(c1ccc(Cl)cc1)N1CCN(c2ccc([N+](=O)[O-])c3ncccc23)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 1/20 1.00
▸ RAB9A P51151 1/20 1.00
▸ SIRT2 Q8IXJ6 1/20 1.00
▸ MAPT P10636 12/20 0.69
▸ ALDH1A1 P00352 8/20 0.69
▸ LMNA P02545 3/20 0.69
▸ SMN1; SMN2 Q16637 7/20 0.68
▸ KMT2A Q03164 2/20 0.56
▸ MAPK1 P28482 4/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ STAT3 P40763 1/20 0.53
▸ TNNI3 P19429 1/20 0.52
▸ TNNT2 P45379 1/20 0.52
▸ TNNC1 P63316 1/20 0.52
▸ SLC6A7 Q99884 1/20 0.52
▸ MITF O75030 1/20 0.52
▸ HTT P42858 1/20 0.52
▸ KDM4E B2RXH2 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29943849 1.00 MTOR (1.00) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24700848 0.96 MTOR (0.93) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL10701562 0.91 MTOR (0.83) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24701133 0.91 MTOR (0.83) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24700862 0.90 MTOR (0.81) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24701354 0.90 MTOR (0.81) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24701302 0.89 MTOR (0.80) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24701383 0.89 MTOR (0.80) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24701014 0.87 MTOR (0.77) MTORRAB9ASIRT2MAPTALDH1A1
SCHEMBL24790147 0.84 MTOR (0.72) MTORRAB9ASIRT2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof ARRAKIS THERAPEUTICS, INC. (US) 2023-11-07 — — US disclosed
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof ARRAKIS THERAPEUTICS, INC. (US) 2023-11-07 — — US disclosed
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2023-10-05 — — US disclosed
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2023-10-05 — — US disclosed
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION ARRAKIS THERAPEUTICS, INC. 2022-12-22 — — US disclosed
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES ARRAKIS THERAPEUTICS, INC. 2022-09-08 — — US disclosed
US-20190270723-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF ARRAKIS THERAPEUTICS, INC. 2019-09-05 — — US disclosed
WO-2017136450-A2 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES ARRAKIS THERAPEUTICS, INC. (US) 2017-08-10 — — WO disclosed
US-20160296523-A1 Sirtuin Modulators as Inhibitors of Cytomegalovirus THE TRUSTEES OF PRINCETON UNIVERSITY 2016-10-13 — — US disclosed
US-20140336178-A1 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES THE GENERAL HOSPITAL CORPORATION (US) 2014-11-13 — — US disclosed
US-20130203733-A1 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2013-08-08 — — US disclosed
US-8404747-B2 Compositions and methods for modulating interaction between polypeptides THE GENERAL HOSPITAL CORPORATION (US) 2013-03-26 — — US disclosed
US-20050239833-A1 Compositions and methods for modulating interaction between polypeptides MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2005-10-27 — — US disclosed
WO-2005087217-A1 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES THE GENERAL HOSPITAL CORPORATION (US) 2005-09-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190270723-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF NSUN3, NSUN2, TARBP1 MTOR 4799/4885RAB9A 4311/4885SIRT2 2859/4885
US-20230312520-A1 NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF NSUN3, NSUN2, TARBP1 MTOR 4799/4885RAB9A 4311/4885SIRT2 2859/4885
US-20160296523-A1 Sirtuin Modulators as Inhibitors of Cytomegalovirus SIRT1, SIRT2, SIRT7 MTOR 358/4885RAB9A 3558/4885SIRT2 2/4885
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES NSUN3, NSUN2, POLRMT MTOR 1869/4885RAB9A 1919/4885SIRT2 1924/4885
US-20050239833-A1 Compositions and methods for modulating interaction between polypeptides IAPP, SERPINA6, SERPINA2 MTOR 3078/4885RAB9A 3139/4885SIRT2 4394/4885
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION NSUN3, NSUN2, METTL16 MTOR 1926/4885RAB9A 2764/4885SIRT2 1593/4885
US-20130203733-A1 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES IAPP, SERPINA6, SERPINA2 MTOR 3078/4885RAB9A 3139/4885SIRT2 4394/4885
US-11807623-B2 Nucleic acid-binding photoprobes and uses thereof NSUN3, NSUN2, TARBP1 MTOR 4799/4885RAB9A 4311/4885SIRT2 2859/4885
US-20140336178-A1 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES IAPP, SERPINA6, SERPINA2 MTOR 3078/4885RAB9A 3139/4885SIRT2 4394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.