Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838229 | 0.94 | KMT2A (0.38) | P2RX3KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL5837923 | 0.92 | KMT2A (0.40) | P2RX3KMT2ARXFP1ALDH1A1MAPT | |
| SCHEMBL5838879 | 0.90 | P2RX7 (0.36) | P2RX3KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL6277608 | 0.89 | P2RX7 (0.35) | CNR2TP53P2RX7CNR1 | |
| SCHEMBL6259712 | 0.88 | P2RY12 (0.34) | RXFP1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL5838235 | 0.88 | P2RX7 (0.36) | P2RX3KMT2ARXFP1MAPTCNR2 | |
| SCHEMBL6259125 | 0.86 | P2RX7 (0.35) | POLBMAPTCNR2TP53P2RX7 | |
| SCHEMBL5838492 | 0.85 | ALDH1A1 (0.37) | KMT2ARXFP1ALDH1A1KDM4EPOLB | |
| SCHEMBL6267685 | 0.85 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL6259544 | 0.85 | P2RX7 (0.32) | CNR2P2RX7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581507-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058731-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |