Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838172 | 0.93 | P2RX7 (0.36) | P2RY12P2RX7CNR2RXFP1MAPT | |
| SCHEMBL5838688 | 0.91 | P2RX7 (0.39) | P2RX7CNR2KDM4EALDH1A1POLB | |
| SCHEMBL5837998 | 0.91 | P2RX7 (0.37) | P2RY12P2RX7CNR2KDM4EALDH1A1 | |
| SCHEMBL5838492 | 0.89 | ALDH1A1 (0.37) | P2RX7CNR2RXFP1MAPTKDM4E | |
| SCHEMBL5837720 | 0.89 | P2RX7 (0.41) | P2RX7CNR2RXFP1MAPTALDH1A1 | |
| SCHEMBL6267690 | 0.88 | P2RX3 (0.35) | P2RX7CNR2RXFP1MAPTKDM4E | |
| SCHEMBL6277608 | 0.88 | P2RX7 (0.35) | P2RX7CNR2CNR1TP53 | |
| SCHEMBL5837880 | 0.87 | P2RX7 (0.38) | P2RX7CNR2RXFP1MAPTKDM4E | |
| SCHEMBL6259710 | 0.86 | P2RX7 (0.45) | P2RX7 | |
| SCHEMBL6259125 | 0.84 | P2RX7 (0.35) | P2RX7CNR2MAPTPOLBCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581507-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058731-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |