Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061994 | 0.85 | SLC6A2 (0.50) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL9320458 | 0.81 | SLC6A2 (0.53) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL16327199 | 0.76 | SLC6A2 (0.62) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL8003701 | 0.74 | TAAR1 (0.44) | CARM1PRMT6PRMT8HTR2AOPRK1 | |
| SCHEMBL10675561 | 0.73 | SLC6A2 (0.69) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL17196573 | 0.73 | SLC6A2 (0.53) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL19203471 | 0.73 | SLC6A2 (0.69) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL530326 | 0.71 | ADRA2B (0.67) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL8435527 | 0.71 | CARM1 (0.69) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| SCHEMBL18055963 | 0.71 | HTR2A (0.60) | CARM1PRMT6PRMT8SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0899264-B1 | 7-Phenyl-1,4-diazepane derivatives as neurokinine receptor antagonists | SOLVAY PHARM GMBH (DE) | 2005-11-23 | — | — | EP | disclosed |
| EP-1218384-A4 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-11-20 | — | — | EP | disclosed |
| EP-1218384-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023392-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-05 | — | — | WO | disclosed |
| US-6040303-A | NEUROKININ-RECEPTOR ANTAGONISTS, ANTIINFLAMMATORY AGENTS FOR TREATING GASTROINTESTINAL DISORDERS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2000-03-21 | — | — | US | disclosed |
| EP-0899264-A1 | 7-Phenyl-1,4-diazepane derivatives as neurokinine receptor antagonists | Solvay Pharmaceuticals GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |