Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TLR3 | O15455 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6270431 | 0.76 | MEN1 (0.46) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL8134327 | 0.75 | KMT2A (0.43) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL8121744 | 0.74 | KMT2A (0.42) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL3193294 | 0.74 | TLR3 (0.59) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL8315997 | 0.74 | CA9 (0.49) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL27330130 | 0.72 | CA9 (0.50) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL8316093 | 0.71 | PTGS1 (0.47) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL6271010 | 0.70 | TLR3 (0.42) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL6976994 | 0.69 | PTGS1 (0.62) | CA9CA12CA1HIF1AEPAS1 | |
| SCHEMBL3258594 | 0.69 | CA9 (0.44) | CA9CA12CA1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995438-B1 | BENZOPYRAN DERIVATIVES FOR THE TREATMENT OF PERIPHERAL VASCULAR DISEASE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2005-11-30 | — | — | EP | disclosed |
| US-6248777-B1 | VASCULAR DISORDERS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-06-19 | — | — | US | disclosed |
| EP-0995438-A1 | REMEDIES FOR PERIPHERAL CIRCULATION DISTURBANCES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0702952-B1 | BENZOPYRAN DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1999-12-08 | — | — | EP | disclosed |
| US-5646310-A | HYPOTENSIVE AGENTS, POTASSIUM CHANNEL ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0702952-A1 | BENZOPYRAN DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1996-03-27 | — | — | EP | disclosed |