Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ESRRG | P62508 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7251718 | 0.99 | TAAR1 (0.36) | GFERTAAR1CHKACYP3A4CYP2D6 | |
| SCHEMBL2923345 | 0.77 | APP (0.36) | — | |
| Bromide SCHEMBL6267968 | 0.76 | APP (0.35) | — | |
| Hydrochloric Acid SCHEMBL7257152 | 0.75 | APP (0.34) | — | |
| Hydrochloric Acid SCHEMBL6268264 | 0.75 | MEN1 (0.33) | CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL20843604 | 0.75 | CHKA (0.46) | GFERCHKACYP3A4MAOAMAOB | |
| Hydrochloric Acid SCHEMBL7251720 | 0.74 | MEN1 (0.35) | CYP3A4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7618823 | 0.73 | APP (0.33) | MAOAMAOB | |
| Hydrochloric Acid SCHEMBL7718851 | 0.73 | PRKCI (0.30) | — | |
| SCHEMBL5154782 | 0.72 | APP (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334713-B1 | Dyeing composition comprising diaminopyrazole and cationic compounds as oxidation bases and a coupling agent | OREAL (FR) | 2005-12-07 | — | — | EP | claimed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | claimed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | claimed |
| EP-0928289-B1 | NOVEL CATIONIC OXIDATION BASES, THEIR USE FOR OXIDATION DYEING OF KERATIN FIBRES, DYEING COMPOSITIONS AND DYEING METHODS | OREAL (FR) | 2004-09-29 | — | — | EP | claimed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | claimed |
| US-6638321-B1 | Oxidation color dyes for hair from aniline compounds | L'OREAL (FR) | 2003-10-28 | — | — | US | claimed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | disclosed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | disclosed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | disclosed |
| US-6638321-B1 | Oxidation color dyes for hair from aniline compounds | L'OREAL (FR) | 2003-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | KRT18, AOC1, CYB5R3 | GFER 206/4885TAAR1 807/4885CHKA 440/4885 |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRT18, AOC1, CYB5R3 | GFER 206/4885TAAR1 807/4885CHKA 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.