Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.69 |
| ▸ | CDK2 | P24941 | 12/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.69 |
| ▸ | MGMT | P16455 | 4/20 | 0.69 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263549 | 0.82 | CDK1 (1.00) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6270509 | 0.76 | CDK2 (0.61) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6268748 | 0.76 | CDK1 (0.43) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL1443987 | 0.76 | PDPK1 (0.56) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL7437649 | 0.74 | PIN1 (0.71) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL5694087 | 0.72 | XDH (0.49) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL6266766 | 0.71 | CDK2 (0.72) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL2877709 | 0.70 | XDH (0.56) | CDK2XDHTMIGD3HTR2CHTR2B | |
| SCHEMBL37384 | 0.69 | DPP4 (0.66) | XDHTMIGD3HTR2CHTR2B | |
| SCHEMBL2114287 | 0.68 | CYP1A2 (0.42) | CDK1CCNB1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017394-B1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2005-12-07 | — | — | EP | disclosed |
| US-6303618-B1 | ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |
| EP-1017394-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999002162-A9 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RES CAMPAIGN TECH (GB) | 1999-07-29 | — | — | WO | disclosed |
| WO-1999002162-A1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |