Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.45 |
| ▸ | THRA | P10827 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269595 | 0.88 | THRB (0.42) | THRBTHRAPTGS1PTGS2MCL1 | |
| SCHEMBL1642728 | 0.86 | THRB (0.45) | THRBTHRAMEN1KMT2AGAA | |
| SCHEMBL1640591 | 0.81 | THRB (0.60) | THRBTHRAMEN1KMT2APTGS1 | |
| SCHEMBL6274795 | 0.78 | THRB (0.45) | THRBTHRAMEN1KMT2AGAA | |
| SCHEMBL1642320 | 0.78 | THRA (0.71) | THRBTHRA | |
| SCHEMBL6273741 | 0.74 | THRB (0.42) | THRBTHRAMEN1KMT2AGAA | |
| SCHEMBL1640505 | 0.74 | THRB (0.47) | THRBTHRAMEN1KMT2AGAA | |
| SCHEMBL4961949 | 0.74 | POLB (0.43) | THRBTHRAGAAGFERPOLB | |
| SCHEMBL6854363 | 0.73 | THRB (0.58) | THRBTHRA | |
| SCHEMBL6861848 | 0.73 | THRB (0.42) | THRBTHRAGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |