Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.45 |
| ▸ | THRA | P10827 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640591 | 0.87 | THRB (0.60) | THRBTHRAPTGS1PTGS2POLB | |
| SCHEMBL6275290 | 0.84 | PTGS1 (0.40) | THRBTHRAPTGS1PTGS2LMNA | |
| SCHEMBL6269595 | 0.82 | THRB (0.42) | THRBTHRAPTGS1PTGS2POLB | |
| SCHEMBL6273242 | 0.80 | THRB (0.49) | THRBTHRA | |
| SCHEMBL6271809 | 0.78 | THRB (0.54) | THRBTHRA | |
| SCHEMBL6269592 | 0.78 | THRB (0.45) | THRBTHRAPTGS1PTGS2POLB | |
| SCHEMBL6275042 | 0.76 | THRA (0.74) | THRBTHRA | |
| SCHEMBL4961949 | 0.74 | POLB (0.43) | THRBTHRAPOLBCOMTHSD17B3 | |
| SCHEMBL6854363 | 0.74 | THRB (0.58) | THRBTHRA | |
| SCHEMBL6861917 | 0.74 | THRB (0.41) | THRBTHRAPOLBCOMTHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |