Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27761216 | 0.82 | NOTUM (0.57) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL21798510 | 0.80 | NOTUM (0.50) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL27652751 | 0.79 | KMT2A (0.53) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL5069267 | 0.79 | ALDH1A1 (0.50) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL28048629 | 0.78 | NOTUM (0.47) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL8918372 | 0.78 | NOTUM (0.55) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL11848148 | 0.76 | NOTUM (0.46) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL27594651 | 0.76 | MAPT (0.56) | NOTUMSMN1; SMN2KMT2AMEN1TDP1 | |
| SCHEMBL8922927 | 0.76 | NOTUM (0.50) | NOTUMSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL27717490 | 0.76 | NOTUM (0.46) | NOTUMSMN1; SMN2POLBTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923370-B1 | ACETYL CHOLINE ESTERASE INHIBITORS FOR TREATING AND DIAGNOSING SLEEP DISORDERED BREATHING | CURAPATH AB (SE) | 2005-11-16 | — | — | EP | disclosed |
| US-6034117-A | Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method | PHARMAPNEA AB (SE) | 2000-03-07 | — | — | US | disclosed |