Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21798510 | 0.84 | NOTUM (0.50) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL27761216 | 0.83 | NOTUM (0.57) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL27822313 | 0.82 | ALDH1A1 (0.47) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL28048629 | 0.81 | NOTUM (0.47) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL8918372 | 0.81 | NOTUM (0.55) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL11848148 | 0.80 | NOTUM (0.46) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL27652751 | 0.80 | KMT2A (0.53) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL27594651 | 0.80 | MAPT (0.56) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL27717490 | 0.80 | NOTUM (0.46) | ALDH1A1HPGDNOTUMTSHRRAB9A | |
| SCHEMBL6269619 | 0.79 | NOTUM (0.49) | ALDH1A1HPGDNOTUMTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292557-B | Pyridopyrimidinone mesoion derivative containing indole unit and preparation method and application thereof | 贵州大学 | 2022-02-11 | — | — | CN | disclosed |
| US-9499484-B2 | Indole, indoline derivatives, compositions comprising them and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2016-11-22 | — | — | US | disclosed |
| US-20150087617-A1 | INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2015-03-26 | — | — | US | disclosed |
| EP-2847165-A2 | INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013150529-A2 | INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2013-10-10 | — | — | WO | disclosed |
| EP-1328515-B1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |
| CN-100334076-C | Indoline derivatives and their use as 5-HT2Use of receptor ligands | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-29 | — | — | CN | disclosed |
| CN-1630636-A | Indoline derivatives and their use as 5-HT2 receptor ligands | HOFFMANN LA ROCHE (CH) | 2005-06-22 | — | — | CN | disclosed |
| EP-1328515-A1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2003-07-23 | — | — | EP | disclosed |
| US-6479534-B1 | Indoline derivatives and method of treating obesity | VERNALIS RESEARCH LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| WO-2002044152-A1 | INDOLINE DERIVATIVES AND THEIR USE AS 5-HT2 RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087617-A1 | INDOLE, INDOLINE DERIVATIVES, COMPOSITIONS COMPRISING THEM AND USES THEREOF | IDO1, INMT, IDO2 | ALDH1A1 840/4885HPGD 1286/4885NOTUM 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.