Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PARG | Q86W56 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269983 | 0.88 | THRB (0.47) | THRBALDH1A1MCOLN3BRD4BRD2 | |
| SCHEMBL6273242 | 0.83 | THRB (0.49) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6268718 | 0.80 | THRB (0.46) | THRBALDH1A1MCOLN3BRD4BRD2 | |
| SCHEMBL6271002 | 0.77 | THRB (0.41) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL1641445 | 0.75 | THRB (0.58) | THRBALDH1A1MCOLN3BRD4BRD2 | |
| SCHEMBL6271809 | 0.72 | THRB (0.54) | THRBTHRA | |
| SCHEMBL1640579 | 0.71 | THRB (0.59) | THRBTHRA | |
| SCHEMBL6270967 | 0.70 | THRB (0.51) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6274988 | 0.69 | THRB (0.51) | THRBALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL6269972 | 0.69 | THRB (0.62) | THRBALDH1A1MCOLN3BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |