Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 12/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | BRD2 | P25440 | 2/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268718 | 0.97 | THRB (0.46) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL1640702 | 0.88 | THRB (0.47) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6794754 | 0.84 | THRB (0.46) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6273242 | 0.84 | THRB (0.49) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL1642115 | 0.84 | THRB (0.47) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6795305 | 0.83 | THRB (0.47) | THRBBRD4BRD2BRD3THRA | |
| SCHEMBL6268739 | 0.83 | THRB (0.54) | THRBTHRA | |
| SCHEMBL6273498 | 0.83 | THRB (0.52) | THRBTHRA | |
| SCHEMBL6273618 | 0.82 | THRB (0.51) | THRBTHRA | |
| SCHEMBL6275290 | 0.80 | PTGS1 (0.40) | THRBTHRASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |