Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.54 |
| ▸ | THRA | P10827 | 7/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | AOC2 | O75106 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642156 | 0.88 | THRB (0.58) | THRBTHRAEGLN1 | |
| SCHEMBL6269563 | 0.86 | THRB (0.58) | THRBTHRAEGLN1 | |
| SCHEMBL6268739 | 0.85 | THRB (0.54) | THRBTHRA | |
| SCHEMBL6274993 | 0.84 | THRB (0.59) | THRBTHRAAOC2MAOA | |
| SCHEMBL6273498 | 0.83 | THRB (0.52) | THRBTHRA | |
| SCHEMBL6273242 | 0.83 | THRB (0.49) | THRBTHRA | |
| SCHEMBL6273618 | 0.82 | THRB (0.51) | THRBTHRAEGLN1MAOA | |
| SCHEMBL6274795 | 0.78 | THRB (0.45) | THRBTHRA | |
| SCHEMBL6275042 | 0.74 | THRA (0.74) | THRBTHRA | |
| SCHEMBL1642036 | 0.74 | THRB (0.72) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |