Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6272881 | 0.84 | ABL1 (0.38) | SMN1; SMN2ABL1MEN1KMT2ALMNA | |
| SCHEMBL6267336 | 0.81 | ABL1 (0.48) | ABL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8333095 | 0.75 | TP53 (0.43) | LMNAMAPT | |
| SCHEMBL6266752 | 0.74 | EGFR (0.48) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6184354 | 0.74 | AHR (0.40) | MEN1KMT2AMAPT | |
| SCHEMBL6273613 | 0.74 | ALOX5 (0.38) | ABL1MAPT | |
| SCHEMBL8321281 | 0.73 | ALOX5 (0.65) | SMN1; SMN2ABL1MEN1KMT2AALDH1A1 | |
| SCHEMBL8333850 | 0.72 | ALOX5 (0.62) | SMN1; SMN2ABL1MEN1KMT2AALDH1A1 | |
| SCHEMBL6256089 | 0.71 | ABL1 (0.41) | ABL1 | |
| SCHEMBL6274420 | 0.70 | ALOX5 (0.42) | ABL1MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005072741-A1 | ((11-OXO-10,11-DIHYDRODIBENZO [B, F] [1, 4] OXAZEPIN-1-YL)OXY) ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CARDIOVASCULAR PREPARATIONS USED TO TREAT ARTERIOLOSCLEROSIS | BAYER HEALTHCARE AG (DE) | 2005-08-11 | — | — | WO | disclosed |
| WO-2005072741-A1 | ((11-OXO-10,11-DIHYDRODIBENZO [B, F] [1, 4] OXAZEPIN-1-YL)OXY) ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS CARDIOVASCULAR PREPARATIONS USED TO TREAT ARTERIOLOSCLEROSIS | BAYER HEALTHCARE AG (DE) | 2005-08-11 | — | — | WO | disclosed |