Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23268398 | 0.78 | HASPIN (0.39) | HASPINKCNH2 | |
| SCHEMBL23268599 | 0.77 | HASPIN (0.38) | HASPINKCNH2FLT3KITPIM1 | |
| SCHEMBL23268407 | 0.76 | HASPIN (0.47) | HASPINKCNH2FLT3PIM1LMNA | |
| SCHEMBL627088 | 0.75 | MAPT (0.32) | HASPINTHRB | |
| SCHEMBL23268370 | 0.75 | HASPIN (0.47) | HASPINKCNH2FLT3KITPIM1 | |
| SCHEMBL627209 | 0.72 | HASPIN (0.40) | HASPINKCNH2FLT3KITPIM1 | |
| SCHEMBL23268328 | 0.71 | HASPIN (0.44) | HASPINKCNH2FLT3PIM1LMNA | |
| SCHEMBL23268288 | 0.71 | LMNA (0.37) | HASPINKCNH2FLT3KITPIM1 | |
| SCHEMBL23725824 | 0.69 | HASPIN (0.41) | HASPINLMNATHRB | |
| SCHEMBL627406 | 0.69 | CYP1A2 (0.46) | HASPINLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |