Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 11/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627210 | 0.78 | PIM1 (0.35) | THRBCHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL23268288 | 0.75 | LMNA (0.37) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL625248 | 0.74 | PIM2 (0.51) | HASPINPIM1KCNH2KITFLT3 | |
| SCHEMBL23268407 | 0.73 | HASPIN (0.47) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL627087 | 0.72 | HASPIN (0.42) | HASPINLMNATHRBPIM1KCNH2 | |
| SCHEMBL12474119 | 0.71 | HASPIN (0.41) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL23268392 | 0.71 | KCNH2 (0.52) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL23725824 | 0.69 | HASPIN (0.41) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL23268337 | 0.69 | HASPIN (0.42) | HASPINLMNATHRBTP53RXFP1 | |
| SCHEMBL23268328 | 0.69 | HASPIN (0.44) | HASPINLMNATHRBTP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |