Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.51 |
| ▸ | THRA | P10827 | 11/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273498 | 0.99 | THRB (0.52) | THRBTHRA | |
| SCHEMBL6268739 | 0.97 | THRB (0.54) | THRBTHRA | |
| SCHEMBL1642414 | 0.88 | THRB (0.53) | THRBTHRAEGLN1 | |
| SCHEMBL1641844 | 0.87 | THRB (0.53) | THRBTHRA | |
| SCHEMBL1641382 | 0.85 | THRB (0.55) | THRBTHRA | |
| SCHEMBL6268718 | 0.82 | THRB (0.46) | THRBTHRA | |
| SCHEMBL6271809 | 0.82 | THRB (0.54) | THRBTHRAMAOAEGLN1 | |
| SCHEMBL6271002 | 0.82 | THRB (0.41) | THRBTHRA | |
| SCHEMBL6270958 | 0.82 | THRB (0.51) | THRBTHRAMAOAMAOBMMP13 | |
| SCHEMBL6272078 | 0.81 | THRA (0.42) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |