Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 6/20 | 0.36 |
| ▸ | THRA | P10827 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640505 | 0.87 | THRB (0.47) | PTGS1PTGS2THRBTHRALMNA | |
| SCHEMBL6274795 | 0.84 | THRB (0.45) | PTGS1PTGS2THRBTHRALMNA | |
| SCHEMBL6273741 | 0.84 | THRB (0.42) | PTGS1PTGS2THRBTHRALMNA | |
| SCHEMBL6274873 | 0.82 | THRA (0.45) | PTGS1PTGS2THRBTHRALMNA | |
| SCHEMBL6273680 | 0.81 | THRB (0.51) | THRBTHRA | |
| SCHEMBL6275882 | 0.80 | THRA (0.51) | THRBTHRA | |
| SCHEMBL1642728 | 0.80 | THRB (0.45) | PTGS1PTGS2THRBTHRALMNA | |
| SCHEMBL6271002 | 0.80 | THRB (0.41) | THRBTHRASMN1; SMN2 | |
| SCHEMBL6274415 | 0.80 | THRB (0.35) | PTGS1PTGS2THRBTHRAKDM4E | |
| SCHEMBL6273498 | 0.78 | THRB (0.52) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | claimed |