Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892961 | 0.85 | NPSR1 (0.48) | NPSR1GAAALDH1A1CYP1A2LMNA | |
| SCHEMBL10790983 | 0.75 | ENPP3 (0.53) | MAPTENPP3 | |
| SCHEMBL706420 | 0.70 | ATM (0.73) | NPSR1GAAALDH1A1LMNAKMT2A | |
| SCHEMBL31014288 | 0.70 | ATM (0.73) | NPSR1GAAALDH1A1LMNAKMT2A | |
| SCHEMBL7890686 | 0.69 | LRRK2 (0.44) | GAAALDH1A1CYP1A2LMNAHTT | |
| SCHEMBL28346770 | 0.68 | ESR1 (0.59) | ALDH1A1KMT2AMEN1MAPTHTR2A | |
| SCHEMBL28430363 | 0.67 | ESR1 (0.56) | LMNA | |
| SCHEMBL31359722 | 0.67 | KMT2A (0.57) | NPSR1GAANLRP3ALDH1A1CYP1A2 | |
| SCHEMBL1396090 | 0.67 | KMT2A (0.57) | NPSR1GAANLRP3ALDH1A1CYP1A2 | |
| SCHEMBL1789226 | 0.67 | NPSR1 (0.64) | NPSR1GAAALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018158777-A1 | IMPROVED PROCESS FOR THE PREPARATION OF CHLORTHALIDONE | MYLAN LABORATORIES LIMITED (IN) | 2018-09-07 | — | — | WO | disclosed |
| WO-2005065046-A2 | AN EFFICIENT INDUSTRIAL PROCESS FOR 3-HYDROXY-3-(3’-SULFAMYL-4’-CHLOROPHENYL)PHTALIMIDINE | IPCA LABORATORIES LIMITED (IN) | 2005-07-21 | — | — | WO | disclosed |
| EP-0051215-B1 | METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF 3-ARYL-3-HYDROXY-PHTHALIMIDINES | USV PHARMACEUTICAL CORPORATION (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4477675-A | SULFONATION OF A 3-PHENYLPHTHALIMIDINE; OXIDATION TO OBTAIN THE 3-HYDROXY DERIVATIVE | USV PHARMACEUTICAL CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4331600-A | 3-/HALOSULFONYL OR SULFAMYLPHENYL/PHTHALIMIDINE, HYPOTENSIVE AGENTS, DIURETICS | USV PHARMACEUTICAL CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0051215-A2 | Methods and intermediates for the synthesis of 3-aryl-3-hydroxy-phthalimidines | USV PHARMACEUTICAL CORPORATION (US) | 1982-05-12 | — | — | EP | disclosed |
| EP-0051217-A1 | Oxidation process | USV PHARMACEUTICAL CORPORATION (US) | 1982-05-12 | — | — | EP | disclosed |