Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 7/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627168 | 0.84 | CCNE1 (0.39) | IKBKBCDK2 | |
| SCHEMBL628244 | 0.83 | MAPK1 (0.36) | CDK2FYN | |
| SCHEMBL627850 | 0.81 | JAK1 (0.35) | PIM1CCNA2CDK2FYN | |
| SCHEMBL627315 | 0.81 | MKNK1 (0.37) | ACHEFYN | |
| SCHEMBL627884 | 0.80 | CCNA2 (0.50) | CCNA2CDK2 | |
| SCHEMBL625118 | 0.78 | POLB (0.31) | POLB | |
| SCHEMBL626399 | 0.76 | KDM1A (0.38) | CCNA2CDK2 | |
| SCHEMBL627199 | 0.74 | FYN (0.46) | POLBKAT2BCCNA2CDK2CCNA1 | |
| SCHEMBL2257064 | 0.71 | MKNK1 (0.44) | PIM1ACHECDK2FYN | |
| SCHEMBL623435 | 0.70 | PIM1 (0.46) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |