Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 12/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627167 | 0.84 | FYN (0.46) | FYNHASPINCDK2JAK2JAK3 | |
| SCHEMBL628243 | 0.83 | FYN (0.46) | FYNHASPINMKNK1 | |
| SCHEMBL627017 | 0.82 | FYN (0.47) | FYNHASPIN | |
| SCHEMBL627849 | 0.82 | FYN (0.46) | FYNHASPINMKNK1JAK1JAK3 | |
| SCHEMBL626175 | 0.82 | FYN (0.46) | FYNHASPINMKNK1 | |
| SCHEMBL627314 | 0.81 | MKNK1 (0.53) | FYNHASPINMKNK1 | |
| SCHEMBL627262 | 0.80 | CCNA2 (0.48) | FYNCCNA2CDK2JAK1 | |
| SCHEMBL627384 | 0.79 | FYN (0.48) | FYNHASPINMKNK1 | |
| SCHEMBL625117 | 0.78 | FYN (0.42) | FYNHASPINMKNK1 | |
| SCHEMBL627106 | 0.76 | FYN (0.44) | FYNHASPINJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |