Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627193 | 0.94 | BTK (0.46) | CKS1BSKP1SKP2CTSKSUV39H2 | |
| SCHEMBL628264 | 0.89 | BTK (0.51) | CTSKBTKJAK3MAPTPDE10A | |
| SCHEMBL626887 | 0.85 | CKS1B (0.48) | CKS1BSKP1SKP2SUV39H2MAPT | |
| SCHEMBL626399 | 0.82 | KDM1A (0.38) | CKS1BSKP1SKP2CTSKBTK | |
| SCHEMBL627265 | 0.79 | CKS1B (0.41) | CKS1BSKP1SKP2MAPTMAP4K4 | |
| SCHEMBL627225 | 0.79 | CKS1B (0.48) | CKS1BSKP1SKP2CTSKOPRM1 | |
| SCHEMBL626211 | 0.79 | IRAK1 (0.48) | CKS1BSKP1SKP2SUV39H2MAPT | |
| SCHEMBL625132 | 0.76 | CKS1B (0.42) | CKS1BSKP1SKP2MAPTRET | |
| SCHEMBL628000 | 0.76 | MAPT (0.42) | MAPT | |
| SCHEMBL628407 | 0.75 | CYP11B2 (0.44) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |