Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.43 |
| ▸ | SKP1 | P63208 | 2/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628406 | 0.90 | CYP11B2 (0.44) | GPR119LMNATHRBTSHR | |
| SCHEMBL627266 | 0.87 | CYP11B2 (0.41) | GPR119ALDH1A1 | |
| SCHEMBL627512 | 0.87 | CKS1B (0.36) | CKS1BSKP1SKP2GPR119LMNA | |
| SCHEMBL627206 | 0.85 | USP30 (0.42) | GPR119LMNATHRB | |
| SCHEMBL627421 | 0.84 | RET (0.44) | TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL627225 | 0.79 | CKS1B (0.48) | CKS1BSKP1SKP2LMNATHRB | |
| SCHEMBL627262 | 0.79 | CCNA2 (0.48) | GPR119MAPTALDH1A1 | |
| SCHEMBL625491 | 0.78 | NAMPT (0.41) | GPR119 | |
| SCHEMBL622972 | 0.77 | GPR119 (0.45) | GPR119 | |
| SCHEMBL627014 | 0.77 | ACKR3 (0.63) | GPR119LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |